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0 0.5 1 1.5 2+ Mortality 27% Improvement Relative Risk Recovery 22% c19rmd.com Beigel et al. Remdesivir for COVID-19 RCT LATE TREATMENT Favors remdesivir Favors control
Beigel, 1,062 patient remdesivir late treatment RCT: 27% lower mortality [p=0.07] and 22% improved recovery [p=0.0005] https://c19p.org/beigel
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Remdesivir for the Treatment of Covid-19 — Final Report
Beigel et al., NEJM, doi:10.1056/NEJMoa2007764
8 Oct 2020    Source   PDF   Share   Tweet
RCT 1,062 hospitalized patients showing faster recovery time with treatment, median 10 days vs. 15 days for placebo, rate ratio for recovery 1.29, p<0.001. Day 29 mortality was 11.4% with remdesivir and 15.2% with placebo, hazard ratio HR 0.73 [0.52-1.03].
[Gérard, Zhou] show significantly increased risk of acute kidney injury with remdesivir.
risk of death, 27.0% lower, HR 0.73, p = 0.07, treatment 541, control 521.
risk of no recovery, 22.5% lower, RR 0.78, p < 0.001, treatment 541, control 521.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Beigel et al., 10/8/2020, Randomized Controlled Trial, USA, North America, peer-reviewed, 12 authors, average treatment delay 9.0 days.
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Late treatment
is less effective
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