Remdesivir-based therapy improved recovery of patients with COVID-19 in the SARSTer multicentre, real-world study

11/3 Late treatment study

Flisiak et al., medRxiv, doi:10.1101/2020.10.30.20215301 (Preprint)
Remdesivir-based therapy improved recovery of patients with COVID-19 in the SARSTer multicentre, real-world study

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Retrospective study comparing 122 remdesivir patients and 211 lopinavir/ritonavir patients, showing higher rates of clinical improvement with remdesivir and lower mortality (not statistically significant).

Flisiak et al., 11/3/2020, retrospective, Poland, Europe, preprint, 23 authors.

all patients, 48.9% lower, RR 0.51, p = 0.18, treatment 5 of 122 (4.1%), control 17 of 211 (8.1%), odds ratio converted to relative risk.

SpO2<95%, 58.0% lower, RR 0.42, p = 0.13, treatment 4 of 82 (4.9%), control 14 of 119 (11.8%), odds ratio converted to relative risk.

no clinical improvement, 56.5% lower, RR 0.44, p = 0.01, treatment 9 of 122 (7.4%), control 36 of 211 (17.1%), odds ratio converted to relative risk.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

All 29 studies All Outcomes

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