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0 0.5 1 1.5 2+ Mortality 20% Improvement Relative Risk Improvement at day 28 35% c19rmd.com Garibaldi et al. Remdesivir for COVID-19 LATE Favors remdesivir Favors control
Garibaldi, 606 patient remdesivir late treatment study: 20% lower mortality [p=0.44] and 35% better improvement [p<0.0001] https://c19p.org/garibaldi
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Effectiveness of remdesivir with and without dexamethasone in hospitalized patients with COVID-19
Garibaldi et al., medRxiv, doi:10.1101/2020.11.19.20234153 (Preprint)
20 Nov 2020    Source   PDF   Share   Tweet
Retrospective 303 remdesivir patients and 303 matched controls showing significantly faster clinical improvement, and lower (but not statistically significant) mortality.
[Gérard, Zhou] show significantly increased risk of acute kidney injury with remdesivir.
risk of death, 20.0% lower, HR 0.80, p = 0.44, treatment 23 of 303 (7.6%), control 45 of 303 (14.9%), adjusted per study.
risk of no improvement at day 28, 35.0% better, RR 0.65, p < 0.001, treatment 52 of 303 (17.2%), control 80 of 303 (26.4%), NNT 11, adjusted per study.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Garibaldi et al., 11/20/2020, retrospective, USA, North America, preprint, 10 authors.
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Late treatment
is less effective
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