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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 20% Improvement Relative Risk Improvement at day 28 35% c19rmd.com/garibaldi.html Favors remdesivir Favors control
20 November 2020 - Late treatment study
Effectiveness of remdesivir with and without dexamethasone in hospitalized patients with COVID-19
Garibaldi et al., medRxiv, doi:10.1101/2020.11.19.20234153 (Preprint)
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Retrospective 303 remdesivir patients and 303 matched controls showing significantly faster clinical improvement, and lower (but not statistically significant) mortality.
risk of death, 20.0% lower, RR 0.80, p = 0.44, treatment 23 of 303 (7.6%), control 45 of 303 (14.9%), NNT 14, adjusted per study.
risk of no improvement at day 28, 35.0% better, RR 0.65, p < 0.001, treatment 52 of 303 (17.2%), control 80 of 303 (26.4%), NNT 11, adjusted per study.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Garibaldi et al., 11/20/2020, retrospective, USA, North America, preprint, 10 authors.
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