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0 0.5 1 1.5 2+ Hospitalization time 9% Improvement Relative Risk Hospitalization time (b) 22% Viral clearance 0% c19rmd.com Goldberg et al. Remdesivir for COVID-19 LATE Favors remdesivir Favors control
Goldberg, 142 patient remdesivir late treatment study: 9% shorter hospitalization [p=0.77] and no change in viral clearance [p=0.98] https://c19p.org/goldberg
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A real-life setting evaluation of the effect of remdesivir on viral load in COVID-19 patients admitted to a large tertiary center in Israel
Goldberg et al., Clinical Microbiology and Infection, doi:10.1016/j.cmi.2021.02.029
9 Mar 2021    Source   PDF   Share   Tweet
Retrospective 29 remdesivir patients and 113 controls, not finding a significant difference in nasopharyngeal viral load or hospitalization time. Hospitalization time was lower with treatment, with a larger reduction for non-intubated patients, although not statistically significant in both cases.
[Gérard, Zhou] show significantly increased risk of acute kidney injury with remdesivir.
hospitalization time, 9.2% lower, relative time 0.91, p = 0.77, treatment 29, control 113.
hospitalization time, 21.8% lower, relative time 0.78, p = 0.30, non-intubated patients only.
risk of no viral clearance, 0.1% lower, RR 1.00, p = 0.98, treatment 29, control 113, relative change in Ct values.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Goldberg et al., 3/9/2021, retrospective, Israel, Middle East, peer-reviewed, 7 authors.
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