Retrospective 29 remdesivir patients and 113 controls, not finding a significant difference in nasopharyngeal viral load or hospitalization time. Hospitalization time was lower with treatment, with a larger reduction for non-intubated patients, although not statistically significant in both cases.
hospitalization time, 9.2% lower, relative time 0.91, p = 0.77, treatment 29, control 113.
hospitalization time, 21.8% lower, relative time 0.78, p = 0.30, non-intubated patients only.
risk of no virological cure, 0.1% lower, RR 1.00, p = 0.98, treatment 29, control 113, relative change in Ct values.
Goldberg et al., 3/9/2021, retrospective, Israel, Middle East, peer-reviewed, 7 authors.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.