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Remdesivir study #19   All Outcomes
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Hospitalization time 9% Imp. Relative Risk, 95% CI Hospitalization time (b) 22% Virological cure 0% Goldberg: A real-life setting evaluation of the effect o.. c19rmd.com/goldberg.html Favors remdesivir Favors control
3/9 Late treatment study
Goldberg et al., Clinical Microbiology and Infection, doi:10.1016/j.cmi.2021.02.029 (Peer Reviewed)
A real-life setting evaluation of the effect of remdesivir on viral load in COVID-19 patients admitted to a large tertiary center in Israel
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Retrospective 29 remdesivir patients and 113 controls, not finding a significant difference in nasopharyngeal viral load or hospitalization time. Hospitalization time was lower with treatment, with a larger reduction for non-intubated patients, although not statistically significant in both cases.
hospitalization time, 9.2% lower, relative time 0.91, p = 0.77, treatment 29, control 113.
hospitalization time, 21.8% lower, relative time 0.78, p = 0.30, non-intubated patients only.
risk of no virological cure, 0.1% lower, RR 1.00, p = 0.98, treatment 29, control 113, relative change in Ct values.
Goldberg et al., 3/9/2021, retrospective, Israel, Middle East, peer-reviewed, 7 authors.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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