Goldman: Remdesivir for 5 or 10 Days in Patients with Severe Covid-19

Remdesivir for 5 or 10 Days in Patients with Severe Covid-19

Goldman et al., NEJM, doi:10.1056/NEJMoa2015301

27 May 2020 Source PDF Share Tweet

RCT of remdesivir for 5 or 10 days with no placebo control group, showing no significant differences between 5 and 10 day treatment. NCT04292899.

[Gérard, Zhou] show significantly increased risk of acute kidney injury with remdesivir.

1. Gérard et al., Clinical Pharmacology & Therapeutics, doi:10.1002/cpt.2145, Remdesivir and Acute Renal Failure: A Potential Safety Signal From Disproportionality Analysis of the WHO Safety Database, https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.2145.

2. Zhou et al., Frontiers in Pharmacology, doi:10.3389/fphar.2022.833679, Acute Kidney Injury and Drugs Prescribed for COVID-19 in Diabetes Patients: A Real-World Disproportionality Analysis, https://www.frontiersin.org/articles/10.3389/fphar.2022.833679/full.

Goldman et al., 5/27/2020, peer-reviewed, 26 authors, trial NCT04292899.

All Studies All Outcomes

This Paper Remdesivir All

Late treatment
is less effective

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