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0 0.5 1 1.5 2+ Mortality 1% Improvement Relative Risk Mechanical ventilation 0% ICU admission -17% c19rmd.com/kuno.html Favors remdesivir Favors control
9 August 2021 - Late treatment study
The association of remdesivir and in-hospital outcomes for COVID-19 patients treated with steroids
Kuno et al., Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkab256 (Peer Reviewed)
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PSM retrospective 3,372 hospitalized patients in the USA treated with steroids, showing no significant difference in mortality with remdesivir, but a lower risk of acute kidney injury.
risk of death, 0.9% lower, RR 0.99, p = 0.96, treatment 214 of 999 (21.4%), control 216 of 999 (21.6%), NNT 499, PSM.
risk of mechanical ventilation, no change, RR 1.00, p = 1.00, treatment 140 of 999 (14.0%), control 140 of 999 (14.0%), PSM.
risk of ICU admission, 17.1% higher, RR 1.17, p = 0.05, treatment 260 of 999 (26.0%), control 222 of 999 (22.2%), PSM.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Kuno et al., 8/9/2021, retrospective, propensity score matching, USA, North America, peer-reviewed, 6 authors.
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