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Home   COVID-19 treatment studies for Remdesivir  COVID-19 treatment studies for Remdesivir  C19 studies: Remdesivir  Remdesivir   Select treatmentSelect treatmentTreatmentsTreatments
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Outcomes in COVID-19 remdesivir studies
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All studies   Exclusions   Mortality   Ventilation   ICU   Hospitalization   Serious outcomes   Viral clearance   RCTs   RCT mortality   Peer-reviewed   All outcomes  
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ All studies 19% 24 97,505 Improvement, Studies, Patients Relative Risk, 95% CI With exclusions 13% 20 81,264 Mortality 19% 23 97,363 Ventilation -38% 6 20,218 ICU admission -17% 1 1,998 Hospitalization -36% 3 2,755 Viral clearance 0% 1 142 RCTs 8% 7 8,325 Peer-reviewed 13% 18 88,829 Late 19% 24 97,505 Remdesivir for COVID-19 c19rmd.com Dec 3, 2021 Favors remdesivir Favors control
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Wang (RCT) -9% 1.09 [0.54-2.18] death 22/158 10/78 Improvement, RR [CI] Treatment Control Olender 59% 0.41 [0.24-0.71] death 24/312 102/818 Spinner (RCT) 35% 0.65 [0.18-2.40] death 5/384 4/200 Pasquini 16% 0.84 [0.69-0.94] death 14/25 24/26 Fried 61% 0.39 [0.15-0.99] death 4/48 2,510/11,673 Beigel (RCT) 27% 0.73 [0.52-1.03] death 541 (n) 521 (n) SOLIDARITY (RCT) 5% 0.95 [0.81-1.11] death 301/2,743 303/2,708 Solh 47% 0.53 [0.39-0.70] death 63/219 202/424 Flisiak 49% 0.51 [0.19-1.30] death 5/122 17/211 Garibaldi 20% 0.80 [0.46-1.41] death 23/303 45/303 Ullah -100% 2.00 [0.67-5.94] death 8/30 4/30 Goldberg 9% 0.91 [0.50-1.67] hosp. time 29 (n) 113 (n) Tsuzuki (PSM) 9% 0.91 [0.45-1.85] death 9/74 26/195 Mahajan (RCT) -76% 1.76 [0.46-6.82] death 5/34 3/36 Mulhem -86% 1.86 [0.21-5.24] death 1/8 515/3,211 Aghajani 19% 0.81 [0.46-1.46] death 46 (n) 945 (n) Arch (PSM) 20% 0.80 [0.64-0.98] death 203/1,491 777/4,676 Barrat-Due (DB RCT) 0% 1.00 [0.20-4.60] death 3/37 4/53 Ohl (PSM) -6% 1.06 [0.83-1.36] death 143/1,172 124/1,172 Madan 44% 0.56 [0.33-0.95] death 23/398 27/260 Kuno (PSM) 1% 0.99 [0.84-1.17] death 214/999 216/999 Diaz 35% 0.65 [0.46-0.92] death 33/286 173/852 Ader (RCT) 6% 0.94 [0.59-1.45] death 34/414 37/418 Mozaffari 12% 0.88 [0.81-0.96] death 4,441/28,855 5,499/28,855 Tau​2​ = 0.02; I​2​ = 56.6% Late treatment 19% 0.81 [0.73-0.89] 5,578/38,728 10,622/58,777 19% improvement All studies 19% 0.81 [0.73-0.89] 5,578/38,728 10,622/58,777 19% improvement 24 remdesivir COVID-19 studies c19rmd.com Dec 3, 2021 Tau​2​ = 0.02; I​2​ = 56.6%; Z = 4.17 Effect extraction pre-specified Favors remdesivir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Wang (RCT) -9% 1.09 [0.54-2.18] death 22/158 10/78 Improvement, RR [CI] Treatment Control Olender 59% 0.41 [0.24-0.71] death 24/312 102/818 Spinner (RCT) 35% 0.65 [0.18-2.40] death 5/384 4/200 Pasquini 16% 0.84 [0.69-0.94] death 14/25 24/26 Beigel (RCT) 27% 0.73 [0.52-1.03] death 541 (n) 521 (n) SOLIDARITY (RCT) 5% 0.95 [0.81-1.11] death 301/2,743 303/2,708 Flisiak 49% 0.51 [0.19-1.30] death 5/122 17/211 Garibaldi 20% 0.80 [0.46-1.41] death 23/303 45/303 Ullah -100% 2.00 [0.67-5.94] death 8/30 4/30 Goldberg 9% 0.91 [0.50-1.67] hosp. time 29 (n) 113 (n) Tsuzuki (PSM) 9% 0.91 [0.45-1.85] death 9/74 26/195 Mahajan (RCT) -76% 1.76 [0.46-6.82] death 5/34 3/36 Aghajani 19% 0.81 [0.46-1.46] death 46 (n) 945 (n) Arch (PSM) 20% 0.80 [0.64-0.98] death 203/1,491 777/4,676 Barrat-Due (DB RCT) 0% 1.00 [0.20-4.60] death 3/37 4/53 Ohl (PSM) -6% 1.06 [0.83-1.36] death 143/1,172 124/1,172 Kuno (PSM) 1% 0.99 [0.84-1.17] death 214/999 216/999 Diaz 35% 0.65 [0.46-0.92] death 33/286 173/852 Ader (RCT) 6% 0.94 [0.59-1.45] death 34/414 37/418 Mozaffari 12% 0.88 [0.81-0.96] death 4,441/28,855 5,499/28,855 Tau​2​ = 0.01; I​2​ = 34.0% Late treatment 13% 0.87 [0.80-0.94] 5,487/38,055 7,368/43,209 13% improvement All studies 13% 0.87 [0.80-0.94] 5,487/38,055 7,368/43,209 13% improvement 20 remdesivir COVID-19 studies after exclusions c19rmd.com Dec 3, 2021 Tau​2​ = 0.01; I​2​ = 34.0%; Z = 3.50 Effect extraction pre-specified Favors remdesivir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Wang (RCT) -9% 1.09 [0.54-2.18] 22/158 10/78 Improvement, RR [CI] Treatment Control Olender 59% 0.41 [0.24-0.71] 24/312 102/818 Spinner (RCT) 35% 0.65 [0.18-2.40] 5/384 4/200 Pasquini 16% 0.84 [0.69-0.94] 14/25 24/26 Fried 61% 0.39 [0.15-0.99] 4/48 2,510/11,673 Beigel (RCT) 27% 0.73 [0.52-1.03] 541 (n) 521 (n) SOLIDARITY (RCT) 5% 0.95 [0.81-1.11] 301/2,743 303/2,708 Solh 47% 0.53 [0.39-0.70] 63/219 202/424 Flisiak 49% 0.51 [0.19-1.30] 5/122 17/211 Garibaldi 20% 0.80 [0.46-1.41] 23/303 45/303 Ullah -100% 2.00 [0.67-5.94] 8/30 4/30 Tsuzuki (PSM) 9% 0.91 [0.45-1.85] 9/74 26/195 Mahajan (RCT) -76% 1.76 [0.46-6.82] 5/34 3/36 Mulhem -86% 1.86 [0.21-5.24] 1/8 515/3,211 Aghajani 19% 0.81 [0.46-1.46] 46 (n) 945 (n) Arch (PSM) 20% 0.80 [0.64-0.98] 203/1,491 777/4,676 Barrat-Due (DB RCT) 0% 1.00 [0.20-4.60] 3/37 4/53 Ohl (PSM) -6% 1.06 [0.83-1.36] 143/1,172 124/1,172 Madan 44% 0.56 [0.33-0.95] 23/398 27/260 Kuno (PSM) 1% 0.99 [0.84-1.17] 214/999 216/999 Diaz 35% 0.65 [0.46-0.92] 33/286 173/852 Ader (RCT) 6% 0.94 [0.59-1.45] 34/414 37/418 Mozaffari 12% 0.88 [0.81-0.96] 4,441/28,855 5,499/28,855 Tau​2​ = 0.02; I​2​ = 58.5% Late treatment 19% 0.81 [0.73-0.89] 5,578/38,699 10,622/58,664 19% improvement All studies 19% 0.81 [0.73-0.89] 5,578/38,699 10,622/58,664 19% improvement 23 remdesivir COVID-19 mortality results c19rmd.com Dec 3, 2021 Tau​2​ = 0.02; I​2​ = 58.5%; Z = 4.14 Favors remdesivir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Fried -37% 1.37 [0.81-2.30] 11/48 1,956/11,673 Improvement, RR [CI] Treatment Control Ullah -250% 3.50 [0.79-15.5] 7/30 2/30 Tsuzuki (PSM) -17% 1.17 [0.37-3.69] 4/74 9/195 Mahajan (RCT) -112% 2.12 [0.41-10.8] 4/34 2/36 Arch (PSM) -68% 1.68 [1.19-2.34] 106/1,498 153/4,602 Kuno (PSM) 0% 1.00 [0.80-1.24] 140/999 140/999 Tau​2​ = 0.07; I​2​ = 58.5% Late treatment -38% 1.38 [1.00-1.91] 272/2,683 2,262/17,535 -38% improvement All studies -38% 1.38 [1.00-1.91] 272/2,683 2,262/17,535 -38% improvement 6 remdesivir COVID-19 mechanical ventilation results c19rmd.com Dec 3, 2021 Tau​2​ = 0.07; I​2​ = 58.5%; Z = 1.93 Favors remdesivir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Kuno (PSM) -17% 1.17 [1.00-1.37] 260/999 222/999 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00; I​2​ = 0.0% Late treatment -17% 1.17 [1.00-1.37] 260/999 222/999 -17% improvement All studies -17% 1.17 [1.00-1.37] 260/999 222/999 -17% improvement 1 remdesivir COVID-19 ICU result c19rmd.com Dec 3, 2021 Tau​2​ = 0.00; I​2​ = 0.0%; Z = 1.98 Favors remdesivir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Goldberg 9% 0.91 [0.50-1.67] hosp. time 29 (n) 113 (n) Improvement, RR [CI] Treatment Control Tsuzuki (PSM) -27% 1.27 [1.10-1.47] hosp. time 74 (n) 195 (n) Ohl (PSM) -100% 2.00 [1.33-3.02] hosp. time 1,172 (n) 1,172 (n) Tau​2​ = 0.06; I​2​ = 64.4% Late treatment -36% 1.36 [0.96-1.94] 0/1,275 0/1,480 -36% improvement All studies -36% 1.36 [0.96-1.94] 0/1,275 0/1,480 -36% improvement 3 remdesivir COVID-19 hospitalization results c19rmd.com Dec 3, 2021 Tau​2​ = 0.06; I​2​ = 64.4%; Z = 1.72 Favors remdesivir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Wang (RCT) -9% 1.09 [0.54-2.18] death 22/158 10/78 Improvement, RR [CI] Treatment Control Olender 59% 0.41 [0.24-0.71] death 24/312 102/818 Spinner (RCT) 35% 0.65 [0.18-2.40] death 5/384 4/200 Pasquini 16% 0.84 [0.69-0.94] death 14/25 24/26 Fried 61% 0.39 [0.15-0.99] death 4/48 2,510/11,673 Beigel (RCT) 27% 0.73 [0.52-1.03] death 541 (n) 521 (n) SOLIDARITY (RCT) 5% 0.95 [0.81-1.11] death 301/2,743 303/2,708 Solh 47% 0.53 [0.39-0.70] death 63/219 202/424 Flisiak 49% 0.51 [0.19-1.30] death 5/122 17/211 Garibaldi 20% 0.80 [0.46-1.41] death 23/303 45/303 Ullah -100% 2.00 [0.67-5.94] death 8/30 4/30 Tsuzuki (PSM) 9% 0.91 [0.45-1.85] death 9/74 26/195 Mahajan (RCT) -76% 1.76 [0.46-6.82] death 5/34 3/36 Mulhem -86% 1.86 [0.21-5.24] death 1/8 515/3,211 Aghajani 19% 0.81 [0.46-1.46] death 46 (n) 945 (n) Arch (PSM) 20% 0.80 [0.64-0.98] death 203/1,491 777/4,676 Barrat-Due (DB RCT) 0% 1.00 [0.20-4.60] death 3/37 4/53 Ohl (PSM) -6% 1.06 [0.83-1.36] death 143/1,172 124/1,172 Madan 44% 0.56 [0.33-0.95] death 23/398 27/260 Kuno (PSM) 1% 0.99 [0.84-1.17] death 214/999 216/999 Diaz 35% 0.65 [0.46-0.92] death 33/286 173/852 Ader (RCT) 6% 0.94 [0.59-1.45] death 34/414 37/418 Mozaffari 12% 0.88 [0.81-0.96] death 4,441/28,855 5,499/28,855 Tau​2​ = 0.02; I​2​ = 58.5% Late treatment 19% 0.81 [0.73-0.89] 5,578/38,699 10,622/58,664 19% improvement All studies 19% 0.81 [0.73-0.89] 5,578/38,699 10,622/58,664 19% improvement 23 remdesivir COVID-19 serious outcomes c19rmd.com Dec 3, 2021 Tau​2​ = 0.02; I​2​ = 58.5%; Z = 4.14 Effect extraction pre-specified Favors remdesivir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Goldberg 0% 1.00 [0.92-1.09] viral+ 29 (n) 113 (n) Improvement, RR [CI] Treatment Control Tau​2​ = 0.00; I​2​ = 0.0% Late treatment 0% 1.00 [0.92-1.09] 0/29 0/113 0% improvement All studies 0% 1.00 [0.92-1.09] 0/29 0/113 0% improvement 1 remdesivir COVID-19 viral clearance result c19rmd.com Dec 3, 2021 Tau​2​ = 0.00; I​2​ = 0.0%; Z = 0.03 Favors remdesivir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Wang (RCT) -9% 1.09 [0.54-2.18] death 22/158 10/78 Improvement, RR [CI] Treatment Control Spinner (RCT) 35% 0.65 [0.18-2.40] death 5/384 4/200 Beigel (RCT) 27% 0.73 [0.52-1.03] death 541 (n) 521 (n) SOLIDARITY (RCT) 5% 0.95 [0.81-1.11] death 301/2,743 303/2,708 Mahajan (RCT) -76% 1.76 [0.46-6.82] death 5/34 3/36 Barrat-Due (DB RCT) 0% 1.00 [0.20-4.60] death 3/37 4/53 Ader (RCT) 6% 0.94 [0.59-1.45] death 34/414 37/418 Tau​2​ = 0.00; I​2​ = 0.0% Late treatment 8% 0.92 [0.81-1.05] 370/4,311 361/4,014 8% improvement All studies 8% 0.92 [0.81-1.05] 370/4,311 361/4,014 8% improvement 7 remdesivir COVID-19 Randomized Controlled Trials c19rmd.com Dec 3, 2021 Tau​2​ = 0.00; I​2​ = 0.0%; Z = 1.27 Effect extraction pre-specified Favors remdesivir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Wang (RCT) -9% 1.09 [0.54-2.18] 22/158 10/78 Improvement, RR [CI] Treatment Control Spinner (RCT) 35% 0.65 [0.18-2.40] 5/384 4/200 Beigel (RCT) 27% 0.73 [0.52-1.03] 541 (n) 521 (n) SOLIDARITY (RCT) 5% 0.95 [0.81-1.11] 301/2,743 303/2,708 Mahajan (RCT) -76% 1.76 [0.46-6.82] 5/34 3/36 Barrat-Due (DB RCT) 0% 1.00 [0.20-4.60] 3/37 4/53 Ader (RCT) 6% 0.94 [0.59-1.45] 34/414 37/418 Tau​2​ = 0.00; I​2​ = 0.0% Late treatment 8% 0.92 [0.81-1.05] 370/4,311 361/4,014 8% improvement All studies 8% 0.92 [0.81-1.05] 370/4,311 361/4,014 8% improvement 7 remdesivir COVID-19 RCT mortality results c19rmd.com Dec 3, 2021 Tau​2​ = 0.00; I​2​ = 0.0%; Z = 1.27 Favors remdesivir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Wang (RCT) -9% 1.09 [0.54-2.18] death 22/158 10/78 Improvement, RR [CI] Treatment Control Olender 59% 0.41 [0.24-0.71] death 24/312 102/818 Spinner (RCT) 35% 0.65 [0.18-2.40] death 5/384 4/200 Pasquini 16% 0.84 [0.69-0.94] death 14/25 24/26 Fried 61% 0.39 [0.15-0.99] death 4/48 2,510/11,673 Beigel (RCT) 27% 0.73 [0.52-1.03] death 541 (n) 521 (n) SOLIDARITY (RCT) 5% 0.95 [0.81-1.11] death 301/2,743 303/2,708 Ullah -100% 2.00 [0.67-5.94] death 8/30 4/30 Goldberg 9% 0.91 [0.50-1.67] hosp. time 29 (n) 113 (n) Mahajan (RCT) -76% 1.76 [0.46-6.82] death 5/34 3/36 Mulhem -86% 1.86 [0.21-5.24] death 1/8 515/3,211 Aghajani 19% 0.81 [0.46-1.46] death 46 (n) 945 (n) Barrat-Due (DB RCT) 0% 1.00 [0.20-4.60] death 3/37 4/53 Ohl (PSM) -6% 1.06 [0.83-1.36] death 143/1,172 124/1,172 Kuno (PSM) 1% 0.99 [0.84-1.17] death 214/999 216/999 Diaz 35% 0.65 [0.46-0.92] death 33/286 173/852 Ader (RCT) 6% 0.94 [0.59-1.45] death 34/414 37/418 Mozaffari 12% 0.88 [0.81-0.96] death 4,441/28,855 5,499/28,855 Tau​2​ = 0.01; I​2​ = 41.9% Late treatment 13% 0.87 [0.79-0.96] 5,252/36,121 9,528/52,708 13% improvement All studies 13% 0.87 [0.79-0.96] 5,252/36,121 9,528/52,708 13% improvement 18 remdesivir COVID-19 peer reviewed trials c19rmd.com Dec 3, 2021 Tau​2​ = 0.01; I​2​ = 41.9%; Z = 2.69 Effect extraction pre-specified Favors remdesivir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Wang (RCT) -9% 1.09 [0.54-2.18] death 22/158 10/78 Improvement, RR [CI] Treatment Control Wang (RCT) 24% 0.76 [0.29-1.95] death 8/71 7/47 Wang (RCT) -48% 1.48 [0.45-4.88] death 12/84 3/31 Olender 59% 0.41 [0.24-0.71] death 24/312 102/818 Spinner (RCT) 35% 0.65 [0.18-2.40] death 5/384 4/200 Pasquini 16% 0.84 [0.69-0.94] death 14/25 24/26 Fried 61% 0.39 [0.15-0.99] death 4/48 2,510/11,673 Fried -37% 1.37 [0.81-2.30] ventilation 11/48 1,956/11,673 Beigel (RCT) 27% 0.73 [0.52-1.03] death 541 (n) 521 (n) SOLIDARITY (RCT) 5% 0.95 [0.81-1.11] death 301/2,743 303/2,708 Solh 47% 0.53 [0.39-0.70] death 63/219 202/424 Flisiak 49% 0.51 [0.19-1.30] death 5/122 17/211 Flisiak 58% 0.42 [0.13-1.18] death 4/82 14/119 Flisiak 56% 0.44 [0.21-0.86] no improv. 9/122 36/211 Garibaldi 20% 0.80 [0.46-1.41] death 23/303 45/303 Garibaldi 35% 0.65 [0.53-0.78] no improv. 52/303 80/303 Ullah -100% 2.00 [0.67-5.94] death 8/30 4/30 Ullah -250% 3.50 [0.79-15.5] ventilation 7/30 2/30 Goldberg 9% 0.91 [0.50-1.67] hosp. time 29 (n) 113 (n) Goldberg 0% 1.00 [0.92-1.09] viral+ 29 (n) 113 (n) Tsuzuki (PSM) 9% 0.91 [0.45-1.85] death 9/74 26/195 Tsuzuki (PSM) -17% 1.17 [0.37-3.69] ventilation 4/74 9/195 Tsuzuki (PSM) -27% 1.27 [1.10-1.47] hosp. time 74 (n) 195 (n) Mahajan (RCT) -76% 1.76 [0.46-6.82] death 5/34 3/36 Mahajan (RCT) -112% 2.12 [0.41-10.8] ventilation 4/34 2/36 Mulhem -86% 1.86 [0.21-5.24] death 1/8 515/3,211 Aghajani 19% 0.81 [0.46-1.46] death 46 (n) 945 (n) Arch (PSM) 20% 0.80 [0.64-0.98] death 203/1,491 777/4,676 Arch (PSM) 18% 0.82 [0.63-1.06] death 140/1,502 565/4,728 Arch (PSM) -68% 1.68 [1.19-2.34] ventilation 106/1,498 153/4,602 Barrat-Due (DB RCT) 0% 1.00 [0.20-4.60] death 3/37 4/53 Ohl (PSM) -6% 1.06 [0.83-1.36] death 143/1,172 124/1,172 Ohl (PSM) -100% 2.00 [1.33-3.02] hosp. time 1,172 (n) 1,172 (n) Madan 44% 0.56 [0.33-0.95] death 23/398 27/260 Madan 66% 0.34 [0.12-0.96] death 4/112 27/260 Madan 62% 0.38 [0.18-0.80] death 9/226 27/260 Madan -60% 1.60 [0.82-3.13] death 10/60 27/260 Kuno (PSM) 1% 0.99 [0.84-1.17] death 214/999 216/999 Kuno (PSM) 0% 1.00 [0.80-1.24] ventilation 140/999 140/999 Kuno (PSM) -17% 1.17 [1.00-1.37] ICU 260/999 222/999 Diaz 35% 0.65 [0.46-0.92] death 33/286 173/852 Ader (RCT) 6% 0.94 [0.59-1.45] death 34/414 37/418 Ader (RCT) 10% 0.90 [0.70-1.15] 7-point status 414 (n) 418 (n) Ader (RCT) -2% 1.02 [0.80-1.30] 7-point status 414 (n) 418 (n) Mozaffari 12% 0.88 [0.81-0.96] death 4,441/28,855 5,499/28,855 Mozaffari 24% 0.76 [0.69-0.83] death 3,057/28,855 4,437/28,855 remdesivir COVID-19 outcomes c19rmd.com Dec 3, 2021 Favors remdesivir Favors control
Please send us corrections, updates, or comments. Vaccines and treatments are both extremely valuable and complementary. All practical, effective, and safe means should be used. Elimination of COVID-19 is a race against viral evolution. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. Denying the efficacy of any method increases the risk of COVID-19 becoming endemic; and increases mortality, morbidity, and collateral damage. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. Treatment protocols for