Association of Remdesivir Treatment With Survival and Length of Hospital Stay Among US Veterans Hospitalized With COVID-19

7/15 Late treatment study

Ohl et al., JAMA Network Open, doi:10.1001/jamanetworkopen.2021.14741 (Peer Reviewed)
Association of Remdesivir Treatment With Survival and Length of Hospital Stay Among US Veterans Hospitalized With COVID-19

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Retrospective 5,898 hospitalized patients in the USA, 2,374 receiving remdesivir treatment, showing no significant difference in mortality, and a longer time to hospital discharge with treatment.

Ohl et al., 7/15/2021, retrospective, propensity score matching, USA, North America, peer-reviewed, 9 authors.

risk of death, 6.0% higher, RR 1.06, p = 0.66, treatment 143 of 1172 (12.2%), control 124 of 1172 (10.6%), adjusted per study, PSM, Cox proportional hazards regression.

hospitalization time, 100% higher, relative time 2.00, p < 0.001, treatment 1172, control 1172, PSM, Cox proportional hazards regression.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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