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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 16% Improvement Relative Risk c19rmd.com/pasquinis.html Favors remdesivir Favors control
23 August 2020 - Late treatment study
Effectiveness of remdesivir in patients with COVID-19 under mechanical ventilation in an Italian ICU
Pasquini et al., Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkaa321 (Peer Reviewed)
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Retrospective 51 ICU patients under mechanical ventilation, 25 treated with remdesivir, showing lower mortality with treatment.
risk of death, 16.2% lower, RR 0.84, p = 0.03, treatment 14 of 25 (56.0%), control 24 of 26 (92.3%), NNT 2.8, adjusted per study, odds ratio converted to relative risk, multivariate.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Pasquini et al., 8/23/2020, retrospective, Italy, Europe, peer-reviewed, 9 authors.
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