Retrospective 51 ICU patients under mechanical ventilation, 25 treated with remdesivir, showing lower mortality with treatment.
Pasquini et al., 8/23/2020, retrospective, Italy, Europe, peer-reviewed, 9 authors.
risk of death, 16.2% lower, RR 0.84, p < 0.001, treatment 14 of 25 (56.0%), control 24 of 26 (92.3%), adjusted per study, odds ratio converted to relative risk, multivariate.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.