Effectiveness of remdesivir in patients with COVID-19 under mechanical ventilation in an Italian ICU

8/23 Late treatment study

Pasquini et al., Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkaa321 (Peer Reviewed)
Effectiveness of remdesivir in patients with COVID-19 under mechanical ventilation in an Italian ICU

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Retrospective 51 ICU patients under mechanical ventilation, 25 treated with remdesivir, showing lower mortality with treatment.

Pasquini et al., 8/23/2020, retrospective, Italy, Europe, peer-reviewed, 9 authors.

risk of death, 16.2% lower, RR 0.84, p < 0.001, treatment 14 of 25 (56.0%), control 24 of 26 (92.3%), adjusted per study, odds ratio converted to relative risk, multivariate.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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