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All Studies   All Outcomes   Recent: 
0 0.5 1 1.5 2+ Mortality 66% Improvement Relative Risk Hospitalization 30% Hospitalization/ER 52% Progression, ER visit 78% c19rmd.com Piccicacco et al. Remdesivir for COVID-19 EARLY Favors remdesivir Favors control
Piccicacco, 172 patient remdesivir early treatment study: 30% lower hospitalization [p=0.47], 52% fewer combined hospitalization/ER visits [p=0.05], and 78% lower progression [p=0.03] https://c19p.org/piccicaccos
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Real-world effectiveness of early remdesivir and sotrovimab in the highest-risk COVID-19 outpatients during the Omicron surge
Piccicacco et al., Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkac256
1 Aug 2022    Source   PDF   Share   Tweet
Retrospective high-risk outpatients in the USA, 82 treated with remdesivir, 88 with sotrovimab, and 90 control patients, showing significantly lower combined hospitalization/ER visits with both treatments in unadjusted results. The dominant variant was omicron B.1.1.529.
[Gérard, Zhou] show significantly increased risk of acute kidney injury with remdesivir.
risk of death, 65.6% lower, RR 0.34, p = 1.00, treatment 0 of 82 (0.0%), control 1 of 90 (1.1%), NNT 90, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 29.
risk of hospitalization, 30.2% lower, RR 0.70, p = 0.47, treatment 7 of 82 (8.5%), control 11 of 90 (12.2%), NNT 27, day 29.
risk of hospitalization/ER, 52.5% lower, RR 0.48, p = 0.05, treatment 9 of 82 (11.0%), control 21 of 90 (23.3%), NNT 8.1, odds ratio converted to relative risk, day 29.
risk of progression, 78.0% lower, RR 0.22, p = 0.03, treatment 2 of 82 (2.4%), control 10 of 90 (11.1%), NNT 12, day 29.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Piccicacco et al., 8/1/2022, retrospective, USA, peer-reviewed, 7 authors, study period 27 December, 2021 - 4 February, 2022, average treatment delay 4.0 days, ER visit.
Contact: npiccicacco@tgh.org.
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