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00.250.50.7511.251.51.752+Wang (RCT)1.09[0.54-2.18]death22/15810/78RRCITreatmentControlOlender0.41[0.24-0.71]death24/312102/818Spinner (RCT)0.65[0.18-2.40]death5/3844/200Pasquini0.84[0.69-0.94]death14/2524/26Fried0.39[0.15-0.99]death4/482,510/11,673Beigel (RCT)0.73[0.52-1.03]death541521SOLIDARITY (RCT)0.95[0.81-1.11]death301/2,743303/2,708Solh0.53[0.39-0.70]death63/219202/424Flisiak0.51[0.19-1.30]death5/12217/211Garibaldi0.80[0.46-1.41]death23/30345/303Ullah2.00[0.67-5.94]death8/304/30Goldberg0.91[0.70-1.17]hosp. time29113Tsuzuki0.91[0.45-1.85]death9/7426/195Mahajan (RCT)1.76[0.46-6.82]death5/343/36Aghajani0.81[0.46-1.46]death46945Tau​2 = 0.07; I​2 = 60.9%Late treatment0.76[0.62-0.92]483/5,0683,250/18,28124% improvementAll studies0.76[0.62-0.92]483/5,0683,250/18,28124% improvement15 remdesivir COVID-19 studiesc19rmd.com 5/15/21Tau​2 = 0.07; I​2 = 60.9%; Z = 2.76 (p = 0.0029)Lower RiskIncreased Risk 00.250.50.7511.251.51.752+Wang (RCT)1.09[0.54-2.18]22/15810/78RRCITreatmentControlOlender0.41[0.24-0.71]24/312102/818Spinner (RCT)0.65[0.18-2.40]5/3844/200Pasquini0.84[0.69-0.94]14/2524/26Fried0.39[0.15-0.99]4/482,510/11,673Beigel (RCT)0.73[0.52-1.03]541521SOLIDARITY (RCT)0.95[0.81-1.11]301/2,743303/2,708Solh0.53[0.39-0.70]63/219202/424Flisiak0.51[0.19-1.30]5/12217/211Garibaldi0.80[0.46-1.41]23/30345/303Ullah2.00[0.67-5.94]8/304/30Tsuzuki0.91[0.45-1.85]9/7426/195Mahajan (RCT)1.76[0.46-6.82]5/343/36Aghajani0.81[0.46-1.46]46945Tau​2 = 0.08; I​2 = 62.3%Late treatment0.74[0.59-0.93]483/5,0393,250/18,16826% improvementAll studies0.74[0.59-0.93]483/5,0393,250/18,16826% improvement14 remdesivir COVID-19 mortality resultsc19rmd.com 5/15/21Tau​2 = 0.08; I​2 = 62.3%; Z = 2.63 (p = 0.0043)Lower RiskIncreased Risk 00.250.50.7511.251.51.752+Goldberg0.91[0.70-1.17]29113RRCITreatmentControlTsuzuki1.27[1.09-1.48]74195Tau​2 = 0.05; I​2 = 79.7%Late treatment1.09[0.79-1.52]0/1030/308-9% improvementAll studies1.09[0.79-1.52]0/1030/308-9% improvement2 remdesivir COVID-19 hospitalization resultsc19rmd.com 5/15/21Tau​2 = 0.05; I​2 = 79.7%; Z = 0.53 (p = 0.3)Lower RiskIncreased Risk 00.250.50.7511.251.51.752+Wang (RCT)1.09[0.54-2.18]death22/15810/78RRCITreatmentControlOlender0.41[0.24-0.71]death24/312102/818Spinner (RCT)0.65[0.18-2.40]death5/3844/200Pasquini0.84[0.69-0.94]death14/2524/26Fried0.39[0.15-0.99]death4/482,510/11,673Beigel (RCT)0.73[0.52-1.03]death541521SOLIDARITY (RCT)0.95[0.81-1.11]death301/2,743303/2,708Solh0.53[0.39-0.70]death63/219202/424Flisiak0.51[0.19-1.30]death5/12217/211Garibaldi0.80[0.46-1.41]death23/30345/303Ullah2.00[0.67-5.94]death8/304/30Goldberg0.91[0.70-1.17]hosp. time29113Tsuzuki0.91[0.45-1.85]death9/7426/195Mahajan (RCT)1.76[0.46-6.82]death5/343/36Aghajani0.81[0.46-1.46]death46945Tau​2 = 0.07; I​2 = 60.9%Late treatment0.76[0.62-0.92]483/5,0683,250/18,28124% improvementAll studies0.76[0.62-0.92]483/5,0683,250/18,28124% improvement15 remdesivir COVID-19 serious outcomesc19rmd.com 5/15/21Tau​2 = 0.07; I​2 = 60.9%; Z = 2.76 (p = 0.0029)Lower RiskIncreased Risk 00.250.50.7511.251.51.752+Wang (RCT)1.09[0.54-2.18]death22/15810/78RRCITreatmentControlWang (RCT)0.76[0.29-1.95]death8/717/47Wang (RCT)1.48[0.45-4.88]death12/843/31Olender0.41[0.24-0.71]death24/312102/818Spinner (RCT)0.65[0.18-2.40]death5/3844/200Pasquini0.84[0.69-0.94]death14/2524/26Fried0.39[0.15-0.99]death4/482,510/11,673Fried1.37[0.81-2.30]ventilation11/481,956/11,673Beigel (RCT)0.73[0.52-1.03]death541521SOLIDARITY (RCT)0.95[0.81-1.11]death301/2,743303/2,708Solh0.53[0.39-0.70]death63/219202/424Flisiak0.51[0.19-1.30]death5/12217/211Flisiak0.42[0.13-1.18]death4/8214/119Flisiak0.44[0.21-0.86]no improv.9/12236/211Garibaldi0.80[0.46-1.41]death23/30345/303Garibaldi0.65[0.53-0.78]no improv.52/30380/303Ullah2.00[0.67-5.94]death8/304/30Ullah3.50[0.79-15.50]ventilation7/302/30Goldberg0.91[0.70-1.17]hosp. time29113Goldberg1.00[1.00-1.00]viral+29113Tsuzuki0.91[0.45-1.85]death9/7426/195Tsuzuki1.17[0.37-3.69]ventilation4/749/195Tsuzuki1.27[1.09-1.48]hosp. time74195Mahajan (RCT)1.76[0.46-6.82]death5/343/36Mahajan (RCT)2.12[0.41-10.82]ventilation4/342/36Aghajani0.81[0.46-1.46]death46945remdesivir COVID-19 outcomesc19rmd.com 5/15/21Lower RiskIncreased Risk
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