Clinical course and outcome of COVID-19 acute respiratory distress syndrome: data from a national repository

10/20 Late treatment study

Solh et al., medRxiv, doi:10.1101/2020.10.16.20214130 (Preprint)
Clinical course and outcome of COVID-19 acute respiratory distress syndrome: data from a national repository

Source PDF Share Tweet

Retrospective database analysis of 7,816 Veterans Affairs hospitalized patients showing 47% reduction in progression from ARDS to mortality.

Solh et al., 10/20/2020, retrospective, database analysis, USA, North America, preprint, 5 authors.

risk of death, 47.0% lower, RR 0.53, p < 0.001, treatment 63 of 219 (28.8%), control 202 of 424 (47.6%), adjusted per study.

This study is excluded in meta analysis: very late stage, >50% on oxygen/ventilation at baseline, substantial unadjusted confounding by indication likely.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

All 29 studies All Outcomes

Please send us corrections, updates, or comments. Vaccines and treatments are both extremely valuable and complementary. All practical, effective, and safe means should be used. Elimination of COVID-19 is a race against viral evolution. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. Denying the efficacy of any method increases the risk of COVID-19 becoming endemic; and increases mortality, morbidity, and collateral damage. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. Treatment protocols for physicians are available from the FLCCC.

Submit