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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 5% Improvement Relative Risk Non-ventilated patients 14% c19rmd.com/solidaritys.html Favors remdesivir Favors control
15 October 2020 - Late treatment study
Repurposed antiviral drugs for COVID-19; interim WHO SOLIDARITY trial results
SOLIDARITY Trial Consortium, NEJM, doi:10.1056/NEJMoa2023184 (preprint 10/15) (Peer Reviewed)
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WHO SOLIDARITY open-label RCT with 2,750 very late stage (76% on oxygen/ventilation) Remdesivir patients, mortality relative risk RR 0.95 [0.81-1.11], p=0.50.
Non-ventilated patients show a greater benefit, RR 0.86 [0.72-1.04], p = 0.13.
risk of death, 5.0% lower, RR 0.95, p = 0.53, treatment 301 of 2,743 (11.0%), control 303 of 2,708 (11.2%), NNT 464.
non-ventilated patients, 14.0% lower, RR 0.86, p = 0.13.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
SOLIDARITY et al., 10/15/2020, Randomized Controlled Trial, multiple countries, multiple regions, peer-reviewed, 15 authors.
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