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Remdesivir study #6 of 16
8/21 Late treatment study
Spinner et al., JAMA, doi:10.1001/jama.2020.16349 (Peer Reviewed)
Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19A Randomized Clinical Trial
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Late stage (median 8 days from symptom onset) RCT 584 patients with moderate COVID-19 showing (non-statistically significant) lower mortality.
5-day remdesivir had significantly higher odds of a better clinical status distribution on the 7-point ordinal scale, odds ratio OR 1.65, p =‚ÄČ0.02. The difference for 10-day remdesivir was not statistically significant, p=0.18.

Spinner et al., 8/21/2020, Randomized Controlled Trial, peer-reviewed, 30 authors.
5 or 10 day remdesivir vs. control 28 day mortality, 34.9% lower, RR 0.65, p = 0.50, treatment 5 of 384 (1.3%), control 4 of 200 (2.0%).

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
Details of all 16 studies
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