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0 0.5 1 1.5 2+ 5 or 10 day remdesivir vs... 35% Improvement Relative Risk c19rmd.com Spinner et al. Remdesivir for COVID-19 RCT LATE TREATMENT Favors remdesivir Favors control
Spinner, 584 patient remdesivir late treatment RCT: 35% lower mortality [p=0.5] https://c19p.org/spinner
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Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19A Randomized Clinical Trial
Spinner et al., JAMA, doi:10.1001/jama.2020.16349
21 Aug 2020    Source   PDF   Share   Tweet
Late stage (median 8 days from symptom onset) RCT 584 patients with moderate COVID-19 showing (non-statistically significant) lower mortality.
5-day remdesivir had significantly higher odds of a better clinical status distribution on the 7-point ordinal scale, odds ratio OR 1.65, p = 0.02. The difference for 10-day remdesivir was not statistically significant, p=0.18.
[Gérard, Zhou] show significantly increased risk of acute kidney injury with remdesivir.
5 or 10 day remdesivir vs. control 28 day mortality, 34.9% lower, RR 0.65, p = 0.50, treatment 5 of 384 (1.3%), control 4 of 200 (2.0%), NNT 143.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Spinner et al., 8/21/2020, Randomized Controlled Trial, multiple countries, multiple regions, peer-reviewed, 30 authors, average treatment delay 8.0 days.
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Late treatment
is less effective
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