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0 0.5 1 1.5 2+ Mortality -4% Improvement Relative Risk Mechanical ventilation or.. 2% Progression 15% c19rmd.com Tsuzuki et al. Remdesivir for COVID-19 LATE TREATMENT Favors remdesivir Favors control
Tsuzuki, 12,487 patient remdesivir late treatment study: 4% higher mortality [p=0.21], 2% lower ventilation [p=0.68], and 15% lower progression [p=0.68] https://c19p.org/tsuzuki
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Efficacy of remdesivir in hospitalized nonsevere COVID-19 patients in Japan: A large observational study using the COVID-19 Registry Japan
Tsuzuki et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2022.02.039 (preprint 3/10/2021)
10 Mar 2021    Source   PDF   Share   Tweet
Retrospective database analysis of 12,487 hospitalized patients in Japan, showing lower risk of oxygen requirement, but no significant difference in mortality or ventilation/ECMO.
[Gérard, Zhou] show significantly increased risk of acute kidney injury with remdesivir.
risk of death, 4.0% higher, HR 1.04, p = 0.21, treatment 69 of 824 (8.4%), control 285 of 11,663 (2.4%), adjusted per study, day 30.
risk of mechanical ventilation or ECMO, 1.7% lower, HR 0.98, p = 0.68, treatment 48 of 824 (5.8%), control 98 of 11,663 (0.8%), adjusted per study.
risk of progression, 15.0% lower, HR 0.85, p = 0.68, treatment 559 of 824 (67.8%), control 1,784 of 11,663 (15.3%), adjusted per study.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Tsuzuki et al., 3/10/2021, retrospective, Japan, Asia, peer-reviewed, 21 authors, average treatment delay 6.0 days.
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Late treatment
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