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0 0.5 1 1.5 2+ Mortality -100% Improvement Relative Risk Ventilation -250% c19rmd.com Ullah et al. Remdesivir for COVID-19 LATE TREATMENT Favors remdesivir Favors control
Ullah, 60 patient remdesivir late treatment study: 100% higher mortality [p=0.33] and 250% higher ventilation [p=0.15] https://c19p.org/ullah
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Efficacy of Remdesivir in Covid-19 Patients; Multicenter Study in Lahore
Ullah et al., International Journal of Sciences, doi:10.18483/ijSci.2417
29 Nov 2020    Source   PDF   Share   Tweet
Small late stage (hospitalized, <12 days symptoms) remdesivir study showing non-statistically significant higher mortality with treatment.
No adjustments were made for differences in the groups. Remdesivir mean age was 49 vs. control 57. Baseline oxygen requirement was 13.4 liters treatment vs. 10.8 control. Potential confounding by indication.
[Gérard, Zhou] show significantly increased risk of acute kidney injury with remdesivir.
risk of death, 100% higher, RR 2.00, p = 0.33, treatment 8 of 30 (26.7%), control 4 of 30 (13.3%).
risk of mechanical ventilation, 250.0% higher, RR 3.50, p = 0.15, treatment 7 of 30 (23.3%), control 2 of 30 (6.7%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ullah et al., 11/29/2020, retrospective, Pakistan, South Asia, peer-reviewed, 8 authors.
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