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30 December 2021 - Animal
Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection
Vermillion et al., Science Translational Medicine, doi:10.1126/scitranslmed.abl8282 (Peer Reviewed)
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African green monkey study of inhaled versus IV remdesivir, showing similar efficacy with inhalation. Comparable concentrations of the active triphosphate in the lower respiratory tract were found with ~20x lower dose using inhalation, and there was lower systemic exposure to remdesivir and metabolites.
Vermillion et al., 12/30/2021, peer-reviewed, 26 authors.
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